A Costimulation-Initiated Signaling Pathway Regulates NFATc1 Transcription in T Lymphocytes
نویسندگان
چکیده
منابع مشابه
A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes.
T cell activation and differentiation is accompanied and mediated by transcriptional reprogramming. The NFATc1 transcription factor is strongly induced upon T cell activation and controls numerous genes involved in the T cell effector function. However, its regulation by physiological stimuli in primary T cells has not been well understood. We previously found that ICOS synergizes with TCR and ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2007
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.179.2.1096